Bacterial metabolism of 5-aminosalicylic acid: enzymic conversion to L-malate, pyruvate and ammonia

Bacterial metabolism of 5-aminosalicylic acid. Initial ring cleavage.

The metabolism of 5-aminosalicylate (5AS) by a bacterial strain, Pseudomonas sp. BN9, was studied. Intact cells of Pseudomonas sp. BN9 grown with 5AS oxidized 5AS and 2,5-dihydroxybenzoate (gentisate), whereas cells grown with gentisate oxidized only the growth substrate of all substituted salicylates tested. Cell extracts from Pseudomonas sp. BN9 catalysed the stoichiometric reaction of 1 mol ...

Formation of sucrose from malate in germinating castor beans. I. Conversion of malate to phosphoenol-pyruvate.

composed of all the valence electrons of the specimen. In this case, the electrons of the metal are coupled via the photon gas; their actions are not completely independent. Such a situation is not the case in the usual photosynthetic system; equilibrium or quasiequilibrium ideas may not be applied. In this situation each photosynthetic event is completely independent of the other events taking...

Metabolism of pyruvate and malate by isolated fat-cell mitochondria.

1. Metabolism of pyruvate and malate by isolated fat-cell mitochondria incubated in the presence of ADP and phosphate has been studied by measuring rates of pyruvate uptake, malate utilization or production, citrate production and oxygen consumption. From these measurements calculations of the flow rates through pyruvate carboxylase, pyruvate dehydrogenase and citrate cycle have been made under...

Electrochemical Synthesis of 5-Aminosalicylic Acid from 5- Nitrosalicylic Acid in Alkaline Media

5-Aminosalicylic acid (5-ASA) is currently prepared by electrochemical reduction of 5-nitrosalicylic acid (5-NSA) in acidic media. In this work, electrolytic reduction of 5-NSA in alkaline media is presented. Reactionconditions and parameters such as anode and cathode electrodes, electrolyte type, reaction time, temperature,current, and the pH for isolation of product are investigated. The yiel...

aminosalicylic acid to 5-aminosalicylic acid in topical treatment of ulcerative colitis. Digestion